CEM Rink Amide ProTide Resin 25 g is engineered with an optimized PEG resin core and advanced Cl-TCP(Cl) and Cl-MPA universal linkers, creating the ideal environment for synthesizing difficult peptides. This unique structure ensures excellent swelling properties and eliminates the need for pre-loaded C-terminal amino acid resins, enabling rapid and efficient direct loading on the resin in just minutes.
Product Features
- Optimized PEG and polystyrene core ensures superior swelling properties for efficient and reliable peptide synthesis.
- Cl-TCP(Cl) and Cl-MPA universal linkers remove the need for pre-loaded C-terminal amino acid resins.
- Supports direct amino acid reaction with linker-chloride using potassium iodide (KI), N,N-diisopropylethylamine (DIEA), and microwave irradiation.
- Automated loading process on Liberty Blue microwave peptide synthesizers with pre-programmed methods.
- High-temperature loading completed in just 10 minutes compared to 24 hours at room temperature.
- Minimizes epimerization and dipeptide formation by avoiding coupling reagents.
- Reduces the need to store over 20 different types of pre-loaded acid-linked resins.
- Excellent hydrolysis stability during storage and handling.
- TCP(Cl) hyperacid sensitivity enables protected peptide production with 1% TFA/DCM and minimizes diketopiperazine and 3-(1-piperidinyl)alanine formation.
- Recommended for synthesis of peptides with amide linkages under 30 amino acids.
- PEG PS core with a loading capacity of 0.6 – 0.8 mmol/g.
- Technical References: Sandhya K., Ravindranath B. Tetrahedron Lett. 49, 2435 (2008); Heinlein C., Silva D., Tröster A., Schmidt J., Gross A., Unverzagt C. Angew. Chem. 50, 6406 (2011).
Key Advantages
- Automated high-temperature loading in just 10 minutes.
- Minimizes side reactions like diketopiperazine and epimerization.
- Streamlines inventory—no need to stock multiple pre-loaded resins.
- High hydrolysis stability for long-term storage and handling.
- Optimized for short to mid-length peptide amide synthesis.
Benefits
- Accelerates peptide synthesis workflows.
- Provides high reproducibility and purity in peptide production.
- Cost-effective and space-saving solution.
- Ideal for routine laboratory use and research applications.
Why Choose CEM Rink Amide ProTide Resin 25 g?
This resin offers unmatched loading speed, minimized side reactions, and reliable performance. Ideal for synthesizing peptides under 30 amino acids, it’s a trusted choice for efficient and high-quality peptide production.
