The MabSelect SuRe 70 HiScreen Column, 1 x 4.7 mL (17542410) is a prepacked protein A affinity chromatography column for monoclonal antibody capture and process development work. Packed with MabSelect SuRe 70 resin, it provides high dynamic binding capacity and an alkali-stable protein A ligand for robust mAb purification workflows.
Key Features
- Prepacked HiScreen format, supplied as a 1 x 4.7 mL column for method development and process screening
- High dynamic binding capacity, with DBC QB10% greater than 70 mg mAb/mL resin at 6 min residence time
- Short residence time performance, with DBC QB10% greater than 65 mg mAb/mL resin at 4 min residence time
- Highly cross-linked agarose matrix, using spherical agarose beads with a 50 µm median particle size
- Alkali-stable protein A-derived ligand, based on an E. coli-derived ligand with single-point attachment
- Epoxy coupling chemistry, supporting stable immobilisation of the affinity ligand
- High-flow resin characteristics, with recommended maximum operating flow velocity of 220 cm/h at 20 cm bed height and 400 cm/h at 10 cm bed height
- Alkaline cleaning compatibility, with CIP stability from 0.1 to 0.5 M NaOH
Benefits
- Supports efficient monoclonal antibody capture where high binding capacity is required.
- Helps improve productivity in protein A capture steps, including short bed height and rapid cycling chromatography workflows.
- Provides a convenient HiScreen column format for method optimisation before scale-up.
- Helps reduce fouling and bioburden risk through compatibility with alkaline cleaning conditions.
- Enables process development using a resin family designed for clinical and commercial-scale mAb production.
Why Choose the MabSelect SuRe 70 HiScreen Column, 1 x 4.7 mL (17542410)?
The MabSelect SuRe 70 HiScreen Column, 1 x 4.7 mL (17542410) is suited to antibody purification teams developing high-productivity protein A capture steps. John Morris Group supplies Cytiva chromatography columns and resins for Australian laboratories and can help confirm suitability for your mAb purification workflow.
