The HiScreen Capto Core 700 Multimodal Column, 4.7 mL (17548115), is a prepacked chromatography column for intermediate purification and polishing of viruses and other large biomolecules. It uses Capto Core 700 multimodal medium in a 4.7 mL HiScreen format, combining size exclusion behaviour with binding chromatography in one column.
Key Features
- Prepacked 4.7 mL column format, supplied as 1 x 4.7 mL for convenient small-scale purification and process development
- Core bead technology, using an inactive shell and ligand-activated core to support flowthrough polishing of large biomolecules
- Multimodal octylamine ligand, providing hydrophobic and positively charged binding sites for smaller impurities entering the bead core
- Large biomolecule polishing use, intended for intermediate purification and polishing of viruses and other large biomolecules
- Defined column geometry, with a 7.7 mm inner diameter and 4.7 mL bed volume
- High-flow operating capability, with a specified flow rate below 500 cm/hr and maximum pressure of 8 bar
- Broad operating pH range, suitable for operation from pH 2 to 14
- Highly cross-linked agarose support, with a 90 µm particle size and polypropylene column material
Benefits
- Helps simplify polishing workflows by allowing large target molecules to pass through while smaller impurities bind inside the bead core.
- Supports method development before scale-up by using a convenient prepacked HiScreen column format.
- Can improve productivity compared with traditional gel filtration approaches in suitable workflows.
- Provides robust process flexibility across a wide pH operating range.
- Reduces the need for manual column packing during small-scale chromatography development.
Why Choose the HiScreen Capto Core 700 Multimodal Column, 4.7 mL (17548115)?
Choose the HiScreen Capto Core 700 Multimodal Column, 4.7 mL (17548115), when you need a prepacked multimodal column for virus and large biomolecule polishing in flowthrough chromatography workflows. John Morris Group can supply this HiScreen chromatography column for Australian laboratories working in purification, process development and scale-up.
