The Capto Core 700 Multimodal Resin, 25 mL (17548101) is a multimodal chromatography resin for intermediate purification and polishing of viruses and other large biomolecules. It uses core bead technology with a ligand-activated core and inactive shell, combining size exclusion and binding behaviour so large targets can pass in the flowthrough while smaller impurities bind inside the bead.
Key Features
- 25 mL bulk resin format, supplied as Capto Core 700 resin for method development and process-scale chromatography workflows
- Dual-mode core bead technology, combining size exclusion behaviour with multimodal binding inside the bead core
- Flowthrough purification design, allowing larger target molecules to pass through while smaller impurities bind to internal ligands
- Octylamine multimodal ligand, providing hydrophobic and positively charged binding functionality
- Highly cross-linked agarose matrix, supporting high-flow operation with reduced back pressure compared with conventional SEC workflows
- Average 85 µm particle size, based on median particle size of the cumulative volume distribution
- Approximately Mr 700 000 molecular weight cutoff, enabling separation of larger targets from smaller contaminants
- High flow capability, with maximum flow velocity of 500 cm/h in a column with 20 cm bed height at less than 2 bar
Benefits
- Supports faster polishing workflows by allowing higher flow rates and higher sample loading than traditional size exclusion chromatography.
- Helps remove smaller impurities such as host cell proteins and nucleic acid fragments while collecting larger target biomolecules in the flowthrough.
- Provides a practical multimodal resin option for virus purification, exosome purification, and large biomolecule polishing workflows.
- Supports process development and scale-up using the same Capto Core 700 resin platform across bulk resin and prepacked formats.
Why Choose the Capto Core 700 Multimodal Resin, 25 mL (17548101)?
The Capto Core 700 Multimodal Resin, 25 mL (17548101) is a suitable choice for laboratories developing flowthrough polishing methods for viruses and other large biomolecules. John Morris Group supplies Cytiva chromatography resins to Australian laboratories, helping users source verified consumables for downstream purification and bioprocess development.
