The Capto Adhere Multimodal Resin, 25 mL (17544410) is a bulk multimodal chromatography resin designed for post-protein A purification of monoclonal antibodies. It is a strong anion exchanger with multimodal functionality, used mainly in flow-through mode to help remove key contaminants while the antibody product passes through the column.
Key Features
- 25 mL bulk resin format, supplied for packing chromatography columns in mAb purification workflows
- Post-protein A purification design, intended for intermediate purification and polishing of monoclonal antibodies after protein A capture
- Multimodal strong anion exchange functionality, giving different selectivity compared with traditional anion exchangers
- N-benzyl-N-methyl ethanolamine ligand, supporting ionic interaction, hydrogen bonding, and hydrophobic interaction
- Highly cross-linked agarose matrix, providing chemical and physical stability for packed bed chromatography
- 75 µm median particle size, supporting process-scale chromatography with high-flow agarose base matrix properties
- Broad pH stability, with short-term pH stability from 2 to 14 and long-term pH stability from 3 to 12
- Flow-through contaminant removal, designed to adsorb leached protein A, antibody aggregates, host cell proteins, nucleic acids, and viruses
Benefits
- Helps streamline monoclonal antibody purification after the protein A capture step.
- Supports a two-step chromatographic process when combined with a protein A capture resin.
- Helps remove multiple contaminant classes in a single polishing step.
- Provides a useful 25 mL bulk format for method development, screening, and small packing requirements.
- Supports process development where pH and conductivity need to be optimised for yield and contaminant clearance.
Why Choose the Capto Adhere Multimodal Resin, 25 mL (17544410)?
The Capto Adhere Multimodal Resin, 25 mL (17544410) is suited to laboratories developing post-protein A purification steps for monoclonal antibodies. John Morris Group supplies Cytiva chromatography resins for Australian laboratories and can help confirm suitability for your mAb purification workflow.
