HiScreen Capto MMC ImpRes Column, 4.7 mL (17371620) is a ready-to-use prepacked chromatography column containing BioProcess Capto MMC ImpRes weak cation exchange multimodal resin. It is designed for method optimisation, parameter screening and high-resolution polishing of monoclonal antibodies and other biomolecules.
Key Features
- Ready-to-use 4.7 mL HiScreen format, supplied as one prepacked column for process development work
- 10 cm bed height, supporting method optimisation, parameter screening and linear scale-up studies
- Capto MMC ImpRes multimodal resin, designed for high-resolution polishing of mAbs, antibody fragments and other biomolecules
- Weak cation exchange multimodal ligand, providing alternative selectivity compared with traditional ion exchange resins
- 40 µm resin particle size, supporting high-resolution polishing in the prepacked column format
- 60 to 90 mg mAb/mL binding capacity, measured as dynamic binding capacity at 10% breakthrough
- Defined flow velocity range, with 100 to 200 cm/h recommended operating flow and 300 cm/h maximum operating flow
- Biocompatible polypropylene column body, with a column hardware pressure limit of 8 bar
Note: HiScreen columns cannot be opened or repacked. Avoid using oxidizing agents and cationic detergents with Capto MMC ImpRes resin.
Benefits
- Helps screen polishing conditions before moving to larger BioProcess column formats.
- Supports effective removal of DNA, host cell proteins, leached protein A, aggregates and viruses in mAb workflows.
- Allows process teams to fine-tune pH, salt and flow conditions using a small, convenient column volume.
- Can be connected in series with another HiScreen column when a 20 cm bed height is required for development work.
Why Choose the HiScreen Capto MMC ImpRes Column, 4.7 mL (17371620)?
HiScreen Capto MMC ImpRes Column, 4.7 mL (17371620) gives laboratories a convenient prepacked format for evaluating Capto MMC ImpRes resin during mAb and biomolecule purification development. John Morris Group supplies this Cytiva column for Australian laboratories needing verified chromatography consumables for process development and polishing studies.
