CEM Rink Amide ProTide Resin (LL) 100 g features an optimized PEG resin core with advanced Cl-TCP(Cl) and Cl-MPA universal linkers, providing an ideal environment for the synthesis of difficult peptides. With excellent swelling properties, this resin eliminates the need for pre-loaded C-terminal amino acid resins and ensures fast, efficient loading directly on the resin.
Product Features
- Optimized PEG and polystyrene core delivers superior swelling properties for challenging peptide synthesis.
- Cl-TCP(Cl) and Cl-MPA universal linkers allow direct loading of C-terminal amino acids, eliminating pre-loaded resin requirements.
- Facilitates amino acid reaction with linker-chloride using potassium iodide (KI), N,N-diisopropylethylamine (DIEA), and microwave irradiation.
- Supports automated loading on Liberty Blue microwave peptide synthesizers with pre-programmed methods.
- Loading completed in just 10 minutes at high temperature (compared to 24 hours at room temperature).
- Epimerization and dipeptide formation are minimized by avoiding coupling reagents.
- Eliminates the need to maintain an inventory of 20+ pre-loaded acid-linked resins.
- Demonstrates strong hydrolysis stability during storage and handling.
- TCP(Cl) is hyperacid sensitive, enabling protected peptide production with 1% TFA/DCM and minimizing diketopiperazine and 3-(1-piperidinyl)alanine formation.
- Recommended for longer and more complex peptide sequences, including those exceeding 75 amino acids.
- TentaGel core with PEG PS and a loading capacity of 0.15 – 0.25 mmol/g.
- Unmatched performance for difficult peptide amide synthesis.
- Technical References: Sandhya K., Ravindranath B. Tetrahedron Lett. 49, 2435 (2008); Heinlein C., Silva D., Tröster A., Schmidt J., Gross A., Unverzagt C. Angew. Chem. 50, 6406 (2011).
Key Advantages
- High-temperature automated loading in 10 minutes for faster workflows.
- Minimizes side reactions such as epimerization and diketopiperazine formation.
- Streamlines resin inventory by removing the need for multiple pre-loaded resins.
- Maintains exceptional stability under storage and handling conditions.
- Ideal for synthesis of long and complex peptide sequences.
Benefits
- Enables efficient and reliable peptide synthesis with minimal preparation time.
- Ensures consistent, high-quality results in automated workflows.
- Reduces reagent use and lowers overall synthesis costs.
- Delivers superior performance for difficult peptide sequences.
Why Choose CEM Rink Amide ProTide Resin (LL) 100 g?
This resin is the ultimate solution for advanced peptide synthesis, offering unmatched efficiency, minimized side reactions, and superior loading performance—ideal for researchers and laboratories working with complex peptide sequences.
