CEM Rink Amide ProTide Resin 5 g features an optimized PEG resin core with advanced Cl-TCP(Cl) and Cl-MPA universal linkers, offering an ideal environment for the synthesis of challenging peptides. The unique structure ensures excellent swelling properties and eliminates the need for pre-loaded C-terminal amino acid resins, enabling rapid and efficient amino acid loading directly onto the resin.
Product Features
- Optimized PEG and polystyrene core ensures superior swelling properties for efficient peptide synthesis.
- Cl-TCP(Cl) and Cl-MPA universal linkers eliminate the need for pre-loaded C-terminal amino acid resins.
- Enables direct amino acid reaction with linker-chloride using potassium iodide (KI), N,N-diisopropylethylamine (DIEA), and microwave irradiation.
- Automated loading process on Liberty Blue microwave peptide synthesizers with pre-programmed software methods.
- Loading is completed in 10 minutes at high temperature (versus up to 24 hours at room temperature).
- Minimizes side reactions such as epimerization and dipeptide formation by avoiding coupling reagents.
- Reduces the need to purchase and store over 20 types of pre-loaded acid-linked resins.
- Exhibits strong hydrolysis stability during storage and handling.
- TCP(Cl) is hyperacid sensitive, enabling protected peptide production with 1% TFA/DCM and minimizing diketopiperazine and 3-(1-piperidinyl)alanine formation.
- Recommended for the synthesis of peptides with amide linkages shorter than 30 amino acids.
- PEG PS core with a loading capacity of 0.6 – 0.8 mmol/g.
- Technical References: Sandhya K., Ravindranath B. Tetrahedron Lett. 49, 2435 (2008); Heinlein C., Silva D., Tröster A., Schmidt J., Gross A., Unverzagt C. Angew. Chem. 50, 6406 (2011).
Key Advantages
- Automated, high-temperature loading in 10 minutes for increased efficiency.
- Reduces side reactions such as diketopiperazine and epimerization.
- Streamlines resin inventory by removing the need for multiple pre-loaded resins.
- High stability during storage and handling.
- Optimized for short to mid-length peptide amide synthesis.
Benefits
- Faster, more efficient peptide synthesis workflows.
- High purity and reproducibility of synthesized peptides.
- Cost-effective solution that reduces storage requirements.
- Ideal for both routine and research laboratory applications.
Why Choose CEM Rink Amide ProTide Resin?
This resin provides unmatched efficiency, minimized side reactions, and superior performance for amide peptide synthesis. Ideal for sequences under 30 amino acids, it’s a powerful solution for modern peptide synthesis workflows.
