CEM Fmoc-Thr(tBu)-OH amino acid, 1kg, is designed for efficient peptide synthesis using ProTide™ resins. These resins feature an optimized PEG and polystyrene core, providing an ideal environment for the synthesis of difficult peptides with excellent swelling properties.
Product Features
- ProTide™ resins with optimized PEG and polystyrene core for difficult peptide synthesis
- Incorporates Cl-TCP(Cl) and Cl-MPA universal linkers, eliminating need for pre-loaded C-terminal amino acids
- C-terminal amino acid reacts with linker-chloride using KI, DIEA, and microwave irradiation
- Automated loading on Liberty Blue microwave peptide synthesizer with pre-programmed methods
- Any amino acid can be loaded onto resins in just 10 minutes
- High-temperature automated procedure avoids coupling reagents, reducing epimerization and dipeptide formation
- No need to buy/store >20 different pre-loaded acid-linked resins
- Strong stability against hydrolysis during storage and handling
- TCP(Cl) is hyperacid sensitive, producing protected peptides with 1% TFA/DCM
- Minimizes diketopiperazine and 3-(1-piperidinyl)alanine formation
- References: Sandhya K., Ravindranath B. Tetrahedron Lett. 49, 2435 (2008); Heinlein C., Silva D., Tröster A., et al. Angew. Chem. 50, 6406 (2011)
Key Advantages
- Automated, high-temperature loading procedure completes in 10 min, vs. 24 hours at room temperature
- Avoids coupling reagents, minimizing epimerization and dipeptide formation
- Eliminates need to buy or store multiple pre-loaded resins
- Strong stability towards hydrolysis during storage and handling
- Minimizes diketopiperazine and 3-(1-piperidinyl)alanine formation for cleaner peptide synthesis
Benefits
- Rapid and reliable amino acid loading for peptide synthesis
- Reduces storage and handling of multiple pre-loaded resins
- High stability ensures reproducible peptide synthesis
- Fully compatible with automated microwave peptide synthesizers
Why Choose CEM Fmoc-Thr(tBu)-OH, 1kg?
Provides a fast, stable, and automated solution for incorporating Fmoc-protected threonine into peptides using advanced ProTide™ resins.
