CEM Fmoc-His(Trt)-OH amino acid is supplied on ProTide™ resins with an optimized PEG and polystyrene core, providing an ideal environment for synthesizing difficult peptides with excellent swelling properties. New Cl-TCP(Cl) and Cl-MPA linkers incorporated onto ProTide eliminate the need to purchase resins pre-loaded with C-terminal amino acids. Any amino acid can be loaded on the resins in 10 minutes using microwave-assisted methods on the Liberty Blue synthesizer.
Product Features
- Optimized PEG and polystyrene core for excellent swelling and peptide synthesis environment
- Cl-TCP(Cl) and Cl-MPA universal linkers eliminate pre-loaded resin requirement
- C-terminal amino acids react with linker-chloride using KI, DIEA, and microwave irradiation
- Automated high-temperature loading procedure complete in 10 min; room temperature can take up to 24 hours
- Avoids coupling reagents, preventing epimerization and dipeptide formation during loading
- No need to buy/store >20 different pre-loaded acid-linked resins
- Strong stability towards hydrolysis during storage and handling
- TCP(Cl) is hyperacid sensitive: produces protected peptides with 1% TFA/DCM, minimizing diketopiperazine and 3-(1-piperidinyl)alanine formation
- Amino Acid: Fmoc-His(Trt)-OH
- Resin Quantity: 100g
Key Advantages
- Fast, automated amino acid loading in 10 minutes compared to 24 hours at room temperature
- Reduces chemical waste and avoids potential side reactions
- Compatible with Liberty Blue microwave peptide synthesizer pre-programmed methods
- Minimizes formation of side products during peptide synthesis
Benefits
- Significantly reduces peptide synthesis time with microwave-assisted loading
- Minimizes handling of multiple pre-loaded resins, reducing storage needs
- Prevents side reactions, improving peptide purity and yield
- Stable and reliable resin for long-term use and storage
- Versatile resin suitable for a wide range of amino acids and peptide sequences
Why Choose CEM Fmoc-His(Trt)-OH Amino Acid, 100g?
This resin provides a reliable, stable, and versatile solution for high-quality peptide synthesis, saving time and reducing chemical handling risks in your lab.
