CEM Cl-TCP(Cl) ProTide Resin (LL), 25g, features an optimized PEG and polystyrene core with Cl-TCP(Cl) and Cl-MPA universal linkers, providing an ideal environment for the synthesis of difficult peptides with excellent swelling properties. This resin allows rapid loading of any C-terminal amino acid in just 10 minutes using automated microwave-assisted methods, eliminating the need for multiple pre-loaded resins.
Product Features
- Optimized PEG resin core with Cl-TCP(Cl) and Cl-MPA universal linkers
- Based on TentaGel PEG PS core with a loading capacity of 0.15 – 0.25 mmol/g
- Enables synthesis of peptides with amide linkages > 30 amino acids
- Activated chloride linker allows attachment of the first amino acid in unactivated form
- Provides steric protection for C-terminal cysteine and proline residues
- Minimizes diketopiperazine and 3-(1-piperidinyl)alanine formation
- Compatible with Liberty Blue microwave peptide synthesizer and pre-programmed software methods
- Fast amino acid loading: 10 minutes at high temperature (room temperature may take up to 24 hours)
Key Advantages
- Avoids coupling reagents, reducing epimerization and dipeptide formation
- Eliminates the need to buy/store multiple pre-loaded resins
- Exhibits strong stability towards hydrolysis during storage and handling
- TCP(Cl) is hyperacid sensitive, producing protected peptides with 1% TFA/DCM
Benefits
- Accelerates peptide synthesis workflow with rapid automated loading
- Minimizes side reactions for higher yield and purity
- Provides steric protection for sensitive amino acids
- Reduces chemical waste and simplifies resin storage
Why Choose CEM Cl-TCP(Cl) ProTide Resin (LL), 25g?
This resin is a reliable, high-performance solution for peptide synthesis, offering excellent swelling properties, rapid automated amino acid loading, and steric protection for challenging C-terminal residues, ensuring high-quality peptide production.
